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Semin Respir Crit Care Med
DOI: 10.1055/a-2591-5502
Review Article

Precision Medicine to Guide Obstructive Sleep Apnea Treatment Beyond the Continuous Positive Airway Pressure

Gonzalo Labarca
1   Department of Respiratory Diseases, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile
2   Division of Pulmonary, Allergy, and Sleep Medicine, Mayo Clinic, Jacksonville, Florida
,
Mario Henríquez-Beltrán
3   Translational Research in Respiratory Medicine, Hospital Universitari Arnau de Vilanova-Santa Maria, Biomedical Research Institute of Lleida (IRBLleida), Lleida, Spain
4   CIBER of Respiratory Diseases (CIBERES), Institute of Health Carlos III, Madrid, Spain
5   Núcleo de Investigación en Ciencias de la Salud, Universidad Adventista de Chile, Chillán, Chile
6   Escuela de Kinesiología, Facultad de Salud, Universidad Santo Tomás, Chile
,
Daniel Solomons
1   Department of Respiratory Diseases, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile
› Author Affiliations
Funding There was no specific funding for the current investigation. G.L. declares grant support from the National Institute of Health and the American Academy of Sleep Medicine, The Chest Foundation; The Sleep Research Society, The ResMed Foundation, and Agencia Nacional de Investigacion y Desarrollo (ANID, Chile, Fondecyt# 11240972).
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Abstract

Obstructive sleep apnea (OSA) is a widespread condition associated with an elevated risk of adverse outcomes. Continuous positive airway pressure (CPAP) is the gold standard treatment, particularly for moderate to severe OSA. However, in many instances, CPAP compliance falls short of expectations, necessitating physicians to consider additional interventions to alleviate patient symptoms. A comprehensive understanding of OSA endotypes and phenotypes can potentially enhance the confidence in selecting the appropriate combination or intervention to improve patient care. In this review, we will discuss various interventions and medications available to enhance the treatment of patients with OSA, following a precision medicine approach.

Keywords

sleep apnea - obstructive - precision medicine - OSA - sleep disorder breathing

Authors' Contributions

Study design: L.M., G.L., and M.H. Data abstraction and collection: D.S., G.L., and M.H. Initial draft: all authors. Review of the manuscript for important intellectual content: L.M., G.L., and M.H. All authors have seen and approved the manuscript.




Publication History

Article published online:
23 May 2025

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